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Peutz Jeghers syndrome

Peutz-Jeghers syndrome - Wikipedi

  1. ant genetic disorder characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa (melanosis)
  2. Peutz-Jeghers syndrome is characterized by the development of noncancerous growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines) and a greatly increased risk of developing certain types of cancer
  3. Peutz-Jeghers syndrome (PJS) is characterized by the association of gastrointestinal polyposis and mucocutaneous pigmentation. The risk for gastrointestinal and extraintestinal malignancies is significantly increased. Distinct benign and malignant gonadal and gynecologic tumors can also be seen
  4. Peutz-Jeghers syndrome (PJS) is a condition where people develop characteristic polyps and dark-colored spots and have an increased risk of certain types of cancer. The gene that is mutated, causing this condition, is responsible for controlling cell growth
  5. What is Peutz-Jeghers syndrome? Peutz-Jeghers syndrome (PJS) is a rare inherited disease that is characterised by gastrointestinal polyps in association with pigmentation affecting skin and mucous membranes. PJS polyps are hamartomas i.e. benign tumours made up of a mixture of mature cells normally found in that tissue
  6. ant polyposis disorder due to germline LKB1 mutations, characterized by intestinal polyposis and mucocutaneous skin pigmentation (Figure 11). PJS has an incidence of around one per 120 000-200 000 live births
  7. Background: The association between heredity, gastrointestinal polyposis, and mucocutaneous pigmentation in Peutz-Jeghers syndrome (PJS) was first recognised in 1921 by Peutz in a Dutch family. This original family has now been followed-up for more than 78 years. We did mutation analysis in this family to test whether the recently identified LKB1 gene is indeed the PJS gene in this family

Le syndrome de Peutz-Jeghers est une affection autosomique dominante caractérisée par des polypes hamartomateux multiples au niveau de l'estomac, de l'intestin grêle et du côlon ainsi que des lésions cutanées pigmentées typiques <개요> 포이츠-제거스 증후군(Peutz-Jeghers syndrome)은 소화관에 발생하는 다발성의 과오종 성 용종 증과 함께 피부점막의 멜라닌 색소침착을 특징으로 하며 주로 상염색체 우성으로 유전되는 질환입니다. 1921년과 1949년에 Peutz와 Jeghers 등에 의하여 각각 보고되었습니다. . 드문 질환으로 6만에서 30만명당. Peutz-Jeghers syndrome (PJS) is an inherited condition that puts people at an increased risk for developing hamartomatous polyps in the digestive tract, as well as cancers of the breast, colon and rectum, pancreas, stomach, testicles, ovaries, lung, cervix, and other types listed below. Without appropriate medical surveillance, the lifetime. A diagnosis of PJS should be considered in a person who satisfies any one of the following: Three or more histologically confirmed polyps Any number of polyps with a family history of PJS Characteristic, prominent, mucocutaneous pigmentation with a family history of PJ

Peutz-Jeghers syndrome (PJS) is an autosomal dominant condition characterized by the association of gastrointestinal polyposis, mucocutaneous pigmentation, and cancer predisposition Peutz-Jeghers Syndome (PJS) is caused by a change or alteration in the STK11 gene on chromosome 19. PJS is a dominantly inherited condition, which means that each child, born to a person with PJS, has a 50% chance of inheriting the altered gene that causes it. How is it diagnosed? PJS is usually diagnosed following an endoscopic procedure Peutz-Jeghers syndrome. Peutz-Jeghers syndrome is a cancer-predisposing disorder that is inherited as an autosomal dominant trait. It is characterized by mucocutaneous pigmentation and. Peutz-Jeghers syndrome. Peutz-Jeghers syndrome is one of the polyposis syndromes. It has an autosomal dominant inheritance and is characterized by: multiple hamartomatous polyps, most commonly involving the small intestine (predominantly the ileum ), but also colon and stomach; mouth and esophagus are spared

Peutz-Jeghers syndrome: MedlinePlus Genetic

Peutz-Jeghers Syndrome - GeneReviews® - NCBI Bookshel

Peutz-Jeghers syndrome is caused by a mutation of the STK11 gene, which is a tumor suppressor gene that codes for a protein called STK11. So without a functioning STK11 gene, the gastrointestinal cells are more likely to accumulate mutations and start dividing faster than usual - ultimately giving rise to polyps Learn the clinical features easily and quickly.Check out my new book HOW TO CONQUER DENTAL SCHOOLHIGHLIGHTS OF THIS BOOK• Assignments to help students intros..

Peutz-Jeghers Syndrome: Symptoms, Causes, Treatment

  1. What is Peutz-Jeghers syndrome? what age does it present and what are the clinical features. The pathology both gross and microscopic of Peutz-Jeghers polyps..
  2. Peutz-Jeghers Syndrome Peutz-Jeghers syndrom Svensk definition. Ärftlig sjukdom orsakad av mutationer i kromosom 19. Kännetecken: förekomsten av tarmpolyper i jejunum och mukokutan melaninfläck pigmentering på läpparna, buckal slemhinna och fingrar
  3. Peutz-Jeghers syndrome is an emerging disease that significantly affects the quality of life enjoyed by patients. Despite of all the progress in improved early diagnostics, options for advanced endoscopic therapy and elaborate surveillance, acute and chronic complications decrease the life expectancy of patients suffering from Peutz-Jeghers.
  4. Peutz-Jeghers syndrome) - genetycznie uwarunkowany zespół cechujący się występowaniem plam soczewicowatych na skórze warg i palców ręki oraz na błonie śluzowej policzków, obecnością polipów hamartomatycznych w przewodzie pokarmowym i predyspozycją do nowotworów złośliwych w różnych narządach
  5. ada síndrome da polipose hereditária intestinal (SPHI) é uma doença genética caracterizada pelo desenvolvimento de pólipos hamartomosos.
  6. Peutz-Jeghers syndrome (PJS) is a condition where people develop characteristic polyps and dark-colored spots and have an increased risk of certain types of cancer. The gene that is mutated, causing this condition, is responsible for controlling cell growth. People with PJS can develop polyps — called Peutz-Jeghers polyps — in the small.
  7. Peutz-Jeghers syndrome (PJS) is caused by changes (mutations) in the STK11 gene. STK11 is a tumor suppressor gene which means that it encodes a protein that helps keep cells from growing and dividing too rapidly or in an uncontrolled way

Peutz-Jeghers syndrome DermNet N

  1. ant condition with mutations in serine/threonine kinase 11 (STK11) and characterised by gastrointestinal polyps in association with pigmentation affecting skin and mucous membranes, and an increased risk for specific cancers
  2. ant inherited disorder characterized by intestinal hamartomatous polyps in association with a distinct pattern of skin and mucosal macular melanin.
  3. ant condition characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous hyperpigmentation. Polyps predo

Peutz-Jeghers syndrome is associated with an increased risk of intestinal cancer (e.g., colorectal and small bowel) and extraintestinal cancer (e.g., breast, pancreas). The lifetime risk for developing cancer is estimated to be up to 93%. Unusual genital tract tumors may occur. Patients require l.. Peutz Jeghers syndrome. Peutz-Jeghers syndrome is a rare inherited disease that is characterized by the development of noncancerous growths called hamartomatous polyps (benign tumors made up of a mixture of mature cells normally found in that tissue) in the gastrointestinal tract particularly the stomach and intestines Clinical features. Mucocutaneous pigmented lesions are common and may be the first clue to an individual having Peutz-Jeghers syndrome; however, this pigmentation may fade over time. Presenting symptoms commonly include GI bleeding, abdominal pain or intussusception

Medical definition of Peutz-Jeghers syndrome: a familial polyposis inherited as an autosomal dominant trait and characterized by numerous polyps in the stomach, small intestine, and colon and by melanin-containing spots on the skin and mucous membranes especially of the lips and gums Peutz-Jeghers syndrome is an inherited condition that often remains undiagnosed until after the polyps are identified, despite mucocutaneous pigmented lesions on the lips and mouth of children or young adults. In the past, standard therapy involved removal of the polyps that produced intussusception, but now endoscopic removal of all polyps is. GI cancer surveillance of Peutz-Jeghers syndrome patients includes colonoscopy, upper endoscopy, and video capsule endoscopy beginning at age 8, with the timing of subsequent surveillance determined by the findings. Surveillance for breast, ovarian, endometrial, and cervical cancer should include breast self-examination starting at age 18 and then starting at age 25 should include annual. Peutz-Jeghers Syndrome. A 14-year-old girl presents to the emergency room with acute abdominal pain and constipation. An ultrasound reveals a target sign, suggesting intussusception. A CT scan confirms this diagnosis Peutz jeghers syndrome 1. Peutz Jeghers Syndrome 2. Peutz-Jeghers syndrome (PJS) Autosomal dominant syndrome characterized by 1. multiple hamartomatous polyps in the gastrointestinal tract 2. mucocutaneous pigmentation 3. an increased risk of gastrointestinal and nongastrointestinal cance

Peutz-Jeghers syndrome (PJS) is a rare inherited disorder that affects approximately 1 in 160,000 to 1 in 280,000 people. Not everyone with Peutz-Jeghers syndrome will develop cancer, but those affected by PJS are at an increased risk, and should undergo regular screening Peutz-Jeghers症候群という病名は1954年にBruwerらによって紹介された。 以下に示す病名も、PJSといった略名で呼ばれている。 Polyp and spots syndrome Inherited hamartomatous polyps in association with mucocutaneous melanocyte macules. Hutchinson Weber-Peutz syndrome . 頻 What Is Peutz-Jeghers Syndrome? The risk for breast and ovarian cancer is increased with Peutz-Jeghers syndrome (PJS), a rare early-onset autosomal dominant disorder, associated with specific physical characteristics in addition to increased cancer risks peutz jeghers syndrome - this is an unpleasant disease. The photos of peutz jeghers syndrome below are not recommended for people with a weak psyche! We wish you a cure and never get sick of this disease! Поделиться на Facebook Skin. epidermoid cyst pictures. Skin. gout in finger pictures Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by GI polyps and mucocutaneous-pigmented macules. Peutz-Jeghers syndrome is 1 of the polyposis syndromes, a group of inherited or acquired conditions characterized by the growth of polyps in the GI tract and associated with other extracolonic features

Peutz-Jeghers Syndrome. Image: A graphical representation of the natural history of Peutz-Jeghers syndrome. Most patients will develop melanotic macules during the first year of life and a patient's first intussusception usually occurs between the ages of six and 18 years old. Cumulative lifetime cancer risk begins to rise in middle age Peutz Jeghers syndrome is a rare disorder that affects males and females in equal numbers and can occur in any racial or ethnic group. The birth prevalence of PJS is estimated to be between 1/50,000 and 1/200,000. Limited evidence shows that the disease might be more prevalent in certain countries such as the Netherlands and China Peutz-Jeghers syndrome is a relatively rare disorder with an estimated incidence of about 1 in 25,000 to 300,000 births. The syndrome can occur in any ethnic group with males and females affected equally. Patients with Peutz-Jeghers syndrome are at an increased risk for developing malignancies; the average age of developing cancer is 42 years 1 Definition. Das Peutz-Jeghers-Syndrom ist eine Erkrankung mit autosomal-dominanter Vererbung, die durch mukokutane Pigmentanomalien und eine generalisierte Polyposis des Gastrointestinaltraktes charakterisiert ist.. 2 Ätiologie. Ursächlich für diese seltene Krankheit ist eine Mutation der Serin-Threonin-Kinase (STK11) auf dem Chromosom 19p13.3. Sie kann bei etwa 70% aller Patienten mit.

A genetic test for Peutz-Jeghers syndrome using next generation sequencing and Sanger sequencing to ensure accurate results Figure 1. Peutz-Jeghers Syndrome. Striking examples of facial (Panel A) and lip (Panel B) pigmentation are shown in an eight-year-old boy with Peutz-Jeghers syndrome, an inherited disorder characte.. Peutz-Jeghers syndrome is a genetic condition that causes non-cancerous growths to develop in the digestive system. The growths, called hamartomatous polyps, usually grow in the small intestine. They can also grow in the stomach or large intestine. Sometimes they grow outside the digestive system and may appear in the kidneys, lungs, gall. Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by melanotic macules, intestinal polyps, and an increased cancer risk. It is caused by mutations in the serine/threonine kinase 11 gene (LKB1, STK11). About 1 in 100,000 individuals have PJS

Pathology Outlines - Peutz-Jeghers polyp

484. 12/29/15, 6:13 PM by Traci. Views: 484. PEUTZ-JEGHERS SYNDROME. I was suspected to have PJS around age 5 due to several freckle spots on and in my mouth, been to several doctors. At age 9 went to have my first endoscopy/colonoscopy and several polyps removed. I had a GI bleed from stress Ulcers the next day a.. 181 Peutz-Jeghers syndrome Instruction Look at this patient's face. Salient features History • Pain in the abdomen as a result of intestinal intussusception • Haemorrhage in the upper GI tract or rectal bleeding • Family involvement (autosomal dominant). Examination • Pigmented freckles around the lips (Fig. 181.1A). Fig. 181.1 Peutz-Jeghers syndrome دليل كيفية النطق: تعلّم كيف تنطق Peutz-Jeghers syndrome فى الإنجليزية بطريقة المتحدث الأصلى. الترجمة الانجليزية لـ Peutz-Jeghers syndrome Oorzaak van het syndroom van Peutz-Jeghers. Het Peutz-Jegherssyndroom is een zeldzame, erfelijke aandoening. Dit syndroom is dominant erfelijk. Dat wil zeggen dat kinderen van iemand met het Peutz-Jegherssyndroom 50% kans hebben om de aandoening van hun ouder te erven

Peutz Jeghers Syndrome - an overview ScienceDirect Topic

Peutz-Jeghers syndrome: 78-year follow-up of the original

Peutz-Jeghers Syndrome and Cancer . Peutz-Jeghers syndrome (PJS) is a rare, inherited condition. It's passed to a child from a parent. PJS is an autosomal dominant genetic disorder. This means you only need one copy of the altered (mutated) gene in order to have PJS. About 3 out of every 4 people diagnosed with PJS have a family history of the. Complications of Peutz-Jeghers syndrome: There is an increased risk of small bowel or colonic adenocarcinoma. There are also risks of cancer of the pancreas, lung, testis, ovary, breast and endometrium. Diagnosis of Peutz-Jeghers syndrome: The diagnosis can be made with genetic testing but this may be inconclusive Peutz-Jeghers Syndrome. Peutz-Jeghersov sindrom (često skraćeno PJS) je autosomno dominantni genetički poremećaj karakteriziran razvojem benignih hamartomskih polipa u ljudskom gastrointestinalnom traktu i hiperpigmentiranih makula na usnama i usnoj sluznici ( melanoza ). Ovaj sindrom može se klasificirati kao jedan od različito. A case of diagnostic difficulty facing the patient with colonic polyposis secondary to Peutz-Jeghers syndrome, but without family history and pathognomonic clinical features of the disease, is. People with this syndrome have dark moles around the mouth, nose, and eyes, as well as multiple polyps in the intestines. Peutz-Jeghers Syndrome Skip to topic navigatio

Symptoms of Peutz Jeghers syndrome . This autosomal dominant trait is often heralded by the presence of melanin spots on the lips and buccal mucosa. Hamartomas are almost always present on the small intestine and occasionally on the stomach and colon Peutz-Jeghers Syndrome: Most have facial and oral papillomas, fibromas and skin tumors: Perioral mucocutaneous hyperpigmentation: Sessile, smooth muscle not prominent: Polypoid with prominent arborizing smooth muscle bundles in GI polyps: Lacks pseudoinvasion: May have displaced mucosa with pseudoinvasion of underlying muscularis propri Peutz-jeghers Syndrome. 230 likes · 2 talking about this. This is a support group for those who either have been diagnosed with this condition or knows someone who has it. Thank you for your support Diagnostic Criteria. ≥1 hamartomatous polyps if family history of Peutz-Jeghers Syndrome (PJS) Prominent mucocutaneous melanosis if family history of PJS. Prominent mucocutaneous melanosis and ≥1 hamartomatous polyp. Glands composed of epithelial cells of same types as normally seen at site of polyp. Epithelial misplacement (pseudoinvasion. El síndrome de Peutz-Jeghers es una enfermedad autosómica dominante, se caracteriza por la producción y la presencia de pigmentaciones epidérmicas, además de la presencia de hamartomas gastrointestinales; este hecho fue confirmado en 1987 por Giardello, el cual, reporto 31 casos de síndrome de Peutz-Jeghers, con daño gastrointestinal asociado a hamartomas

Peutz-Jeghers syndrome is an autosomal dominant cancer predisposition syndrome characterised by hamartomatous GI tract polyps and mucocutaneous pigmentation [1, 2]. Individuals with PJS are at an increased risk of GI cancers and other malignancies including breast, gynaecological, testicular and pancreatic cancers [3,4,5] Syndrome de peutz-jeghers, Lallaing. 28 likes. Nous récoltons de l'argent afin de faire avancer la recherche contre la maladie. Pour cela, l'association organise des repas, concerts avec le parrain.. Peutz-Jeghers syndrome is caused by mutations in a gene on chromosome 19 known as STK11. Genetic testing is available. A positive family history is found in about half of the people who are diagnosed with PJS. The other half have no previous family history. Almost all people with PJS will be diagnosed with one or more of the associated cancers. Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by melanotic macules, intestinal polyps, and an increased cancer risk. It is caused by mutations in the serine/threonine kinase 11 gene (LKB1, STK11). About 1 in 100,000 individuals have PJS Peutz-Jeghers syndrome (PJS) is a hereditary condition that causes multiple polyps (abnormal growths) called hamartomas in the gastrointestinal (GI) tract. Hamartomas can be found anywhere from the stomach to the rectum, but they are mostly found in the small intestine

Mucosal prolapse in the pathogenesis of Peutz-Jeghers

Syndrome de Peutz-Jeghers - Troubles gastro-intestinaux

Peutz-Jeghers syndrome is a genetic disorder that leads to the formation of gastrointestinal polyps and hyper pigmented macules on the lips and on the mucus in the mouth. It is often inherited and is passed down in families. Individuals with Peutz-Jeghers syndrome are at a greater risk to develop certain cancers Peutz Jeghers syndrome (PJS) is an autosomal dominant genetic condition characterized by multiple benign polyps called hamartomas on the mucous lining in the gastrointestinal system. These polyps occur most often in the small intestine but also occur in the stomach and large intestine. Affected individuals also have dark skin discoloration. Peutz jeghers syndrome is an inherited genetic disorder causes abnormality in mutation and outcome can be noncancerous multiple polyps formation or hamartomas in the mucous membrane of the gastrointestinal tract, specifically in intestine and stomach Peutz-Jeghers syndrome is characterized by the development of noncancerous growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines) and a greatly increased risk of developing certain types of cancer. Summary

Peutz-Jeghers syndrome (PJS) is a rare disorder in which growths called polyps form in the intestines. A person with PJS has a high risk of developing certain cancers. Causes. It is unknown how many people are affected by PJS. However, the National Institutes of Health estimates that it affects about 1 in 25,000 to 300,000 births Peutz-Jeghers syndrome. Peutz-Jeghers polyp, as may be seen in Peutz-Jeghers syndrome. (WC) Peutz-Jeghers syndrome, abbreviated PJS, is a constellation of findings inherited with an autosomal dominant pattern due to a defect in the STK11 gene Peutz-Jeghers syndrome (PJS) is a disorder often passed down through families (inherited) in which the person develops intestinal polyps and is at a significantly higher risk for developing certain cancers. Causes. It is unknown how many people are affected by PJS. However, the National Institutes of Health estimates that it affects about 1 in. Peutz-Jeghers syndrome (PJS) is a rare, inherited condition. It's passed to a child from a parent. PJS is an autosomal dominant genetic disorder. This means you only need one copy of the altered (mutated) gene in order to have PJS. About 3 out of every 4 people diagnosed with PJS have a family history of the disorder

Peutz-Jeghers syndrome (PJS) is characterized by the development of noncancerous growths called hamartomatous polyps in the gastrointestinal tract (particularly the stomach and intestines) and an increased risk of developing certain types of cancer. Malignant tumors are most commonly found in the gastrointestinal tract, pancreas, cervix, ovary. Peutz-Jeghers syndrome is a rare, hereditary condition which typically affects the skin and/or mucous membranes. It may also involve the GI tract later in life. Cutaneous symptoms consist of small, hyperpigmented spots of skin, called macules, which may be blueblack, dark brown or tan in color Peutz Jeghers syndrome. Patients with Peutz-Jeghers syndrome (PJS) have characteristic GI hamartomatous polyps, mucocutaneous pigmentation and predisposition to GI, breast, and other cancers. The prevalence of PJS is between 1/8,300 and 1/29,000. A full description with management guidelines is available Peutz-Jeghers syndrome. Autosomal dominant disorder (1 per 200,000) with variable penetrance, usually diagnosed at age 20 - 30. Hamartomatous polyps in small bowel (100%), stomach and colon (25%) - polyps may occur without other features of syndrome, may be associated with enteritis cystica profunda, may cause intussusception and bleeding Jeghers-peutz syndrome definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now

포이츠-제거스 증후군(Peutz-Jeghers syndrome) : 네이버 블로

Peutz-Jeghers Syndrome Cancer

Peutz-Jeghers-syndrome: A Syndrome gastrointestinal polyposis characterized by specific melanin pigmentations of the skin and mucous membranes Gary Zhang and Mike Cadogan; December 14, 2020; Harold Jeghers . Harold Joseph Jeghers (1904 - 1990) was an American physician. Peutz-Jeghers syndrome (1949 El síndrome de Peutz-Jeghers es un trastorno de herencia autosómica dominante ocasionado por alteración del brazo corto del cromosoma 19 (19p13.3), 1 el gen mutante se conoce como LKB1 o STK11; 2 siendo un gen supresor de tumores, el SPJ representa el primer síndrome de susceptibilidad a cáncer que resulta de la inactivación de la cinasa, lo que origina predisposición a desarrollar. Peutz-Jeghers Syndrome (PJS) is a hereditary cancer predisposing syndrome caused by autosomal dominant mutations in the serine/threonine kinase 11 (STK11) gene and is associated with decreased life expectancy. Many families experience a poorer quality of life due to the psychological burden associated with the carrier status of their child peutz-jeghers syndrome. STUDY. PLAY. how does it occur? autosomal dominat and or spontaneous mutation in 35%. presents. freckle-like lesions in the periorificial areas and possibly skin hamartomatous intestinal polyps leading to intestinal obstruction. location of lesions. mouth nose anus genita

Peutz-Jeghers syndrome - Criteria BMJ Best Practic

Autosomal dominant disorder characterized by mucocutaneous pigmentation and generalized intestinal polyposis. Clinically normal carriers and monosymptomatic cases have been reported. The pigmented macules usually appear in early childhood, but may be present at birth or develop later in life. The oral mucous membrane is almost constantly involved. Patches of brown or almost black pigmentation. Background Peutz-Jeghers syndrome (PJS) is characterized by intestinal polyposis, mucocutaneous pigmentation and an increased cancer risk, usually caused by mutations of the STK11 gene. This study collected epidemiological, clinical and genetic data from all Uruguayan PJS patients. Methods Clinical data were obtained from public and private medical centers and updated annually

Mouth Pigmentation Part 1 | Intelligent Dental

Peutz-Jeghers syndrome - Conditions - GTR - NCB

Photo-Library of PathologyGenetic Colon CancerPPT - Colonic polyps By assistant lecturer: Waleed Fouad

Peutz Jeghers syndrome - St Marks Hospital Polyposis

Peutz-Jeghers syndrome was first described by Peutz in 1921 and Jeghers in 1944 and 1949 (, 1). The syndrome is characterized by mucocutaneous pigmentation and hamartomas of the gastrointestinal system and is seen in both male and female patients with no racial predominance (, 2). It is usually diagnosed during childhood or early adulthood Case Discussion. Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder characterised by intestinal hamartomatous polyps with a distinct pattern of melanin deposition in skin most commonly perioral regions. Patients with PJS are 15-times more prone to develop GI malignancies. PJS patients are at high risk for developing pancreatico-biliary malignancies 1 INTRODUCTION. Peutz-Jeghers syndrome (PJS) is an autosomal dominant syndrome characterized by multiple hamartomatous polyps in the gastrointestinal tract, mucocutaneous pigmentation, and an increased risk of gastrointestinal and nongastrointestinal cancer [].This topic will review the genetic basis, clinical manifestations, and diagnosis of PJS Peutz-Jeghers syndrome (PJS) is a cancer predisposition syndrome characterized by the development of numerous precancerous polyps in the gastrointestinal tract and an increased risk of developing a wide variety of cancers, including colorectal, pancreatic, stomach, small bowel, and lung.Women with PJS also have increased lifetime risk of breast, ovarian, cervical, and uterine cancers